There are two drug-eluting stents available in the U.S. at this time- Johnson & Johnson/Cordis CYPHER and the Boston Scientific TAXUS.
Medtronic ENDEAVOR stent is currently under review by the U.S. FDA and approval is anticipated in the second half of 2007.
Abbott XIENCE V stent application to the U.S. FDA was submitted June 1, 2007. Approval is expected in the first quarter of 2008.
The Medtronic ENDEAVOR stent is based on the cobalt alloy DRIVER stent. It has a Phosphorylcholine polymer licensed from Abbott Laboratories. The ENDEAVOR stent releases a drug called ABT-578, which is also licensed from Abbott Laboratories.
The Abbott XIENCE V stent is based on the Multi-Link Vision stent with Everolimus as the eluting drug. The XIENCE V stent will also be co-marketed by Boston Science as the PROMUS Everloimus Eluting stent. The Multi-Link Vision stent is the same stent developed and marketed by Guidant in the past. The "V" in XIENCE V probably is in reference to "Vision" and not "version 5" of the stent.
Prior to 2006, Abbott did not have a stent product. How Abbott purchased the XIENCE stent from Guidant is quite interesting. In January 2006, Boston Scientific was locked in a bidding war with Johnson & Johnson for Guidant. Boston Scientific really wanted to buy the rhythm management (pacemaker, ICD) division of Guidant. Abbott was able to purchase the vascular device (stent and balloon) division of Guidant from Boston Scientific as part of the deal. The deal between Abbott and Boston Scientific was a mixture of direct payment, stock sales, and low interest loan. Boston Scientific was finally able to purchase Guidant in 2006.